Details
Buy reliable Quality 2-Phenylbutyryl chloride 36854-57-6 raw material with Honest Price
- Molecular Formula: C10H11ClO
- Molecular Weight: 182.65
- Appearance/Colour: Clear pale yellow to yellow liquid
- Vapor Pressure: 0.0343mmHg at 25°C
- Melting Point: 178-180 °C
- Refractive Index: n20/D 1.516(lit.)
- Boiling Point: 242.3 °C at 760 mmHg
- Flash Point: 103.6 °C
- PSA： 17.07000
- Density: 1.11 g/cm3
- LogP: 2.94560
2-Phenylbutyryl chloride(Cas 36854-57-6) Usage
|
General Description |
The kinetic resolution of racemic 2-phenylbutyryl chloride by sterically hindered chiral secondary alcohols has been evaluated. 2-Phenylbutyryl chloride reacts with 4-methoxybenzoyl chloride catalyzed by PdBr(Ph)(PPh3)2 to yield 1-(4-methoxyphenyl)-2-phenyl-2-buten-1-one. |
InChI:InChI=1/C10H11ClO/c1-2-9(10(11)12)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3/t9-/m0/s1
36854-57-6 Relevant articles
Novel Pyridine-Based Hydroxamates and 2′-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity
Zwergel, Clemens,Di Bello, Elisabetta,Fioravanti, Rossella,Conte, Mariarosaria,Nebbioso, Angela,Mazzone, Roberta,Brosch, Gerald,Mercurio, Ciro,Varasi, Mario,Altucci, Lucia,Valente, Sergio,Mai, Antonello
, p. 989 - 999 (2020/12/17)
Starting from the N-hydroxy-3-(4-(2-phen...
Palladium-Catalyzed 2-(Neopentylsulfinyl)aniline Directed C–H Acetoxylation and Alkenylation of Arylacetamides
Barysevich, Maryia V.,Laktsevich-Iskryk, Marharyta V.,Krech, Anastasiya V.,Zhabinskii, Vladimir N.,Khripach, Vladimir A.,Hurski, Alaksiej L.
supporting information, p. 937 - 943 (2020/02/25)
The 2-(neopentylsulfinyl)aniline directi...
Visible-Light-Assisted Gold-Catalyzed Fluoroarylation of Allenoates
Feng, Chao,Tang, Hai-Jun,Zhang, Xinggui,Zhang, Yu-Feng
supporting information, p. 5242 - 5247 (2020/02/28)
A strategically novel synthetic method f...
Isothiourea-Catalyzed Acylative Kinetic Resolution of Tertiary α-Hydroxy Esters
Greenhalgh, Mark D.,Laina-Martín, Víctor,Neyyappadath, Rifahath M.,Qu, Shen,Smith, Andrew D.,Smith, Samuel M.
supporting information, p. 16572 - 16578 (2020/09/09)
A highly enantioselective isothiourea-ca...
36854-57-6 Process route
-
-
90-27-7
2-Phenylbutyric acid
-
-
36854-57-6
2-Phenylbutyryl chloride
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
for 1h;
Heating;
|
100%
|
|
With
thionyl chloride;
|
|
|
With
tetrachloromethane; thionyl chloride;
|
|
|
With
thionyl chloride;
Heating;
|
7.83 g
|
|
With
thionyl chloride;
In
dichloromethane;
for 3h;
Heating;
|
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride;
Ambient temperature;
|
|
|
With
phosphorus pentachloride;
In
tetrachloromethane;
at 40 ℃;
for 0.5h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at -78 ℃;
for 2h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at -78 - 20 ℃;
|
|
|
With
thionyl chloride;
N,N-dimethyl-formamide;
In
dichloromethane;
|
12.4 g (68%)
|
|
With
thionyl chloride;
for 2h;
Reflux;
|
|
|
With
thionyl chloride;
for 2h;
Reflux;
Inert atmosphere;
|
|
|
With
thionyl chloride;
In
toluene;
at 20 - 80 ℃;
|
|
|
With
thionyl chloride;
In
1,2-dichloro-ethane;
for 1h;
Reflux;
|
|
|
With
thionyl chloride;
In
toluene;
at 115 ℃;
|
|
|
With
thionyl chloride;
Reflux;
|
|
|
With
thionyl chloride;
In
N,N-dimethyl-formamide;
at 70 ℃;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
for 24h;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 20 ℃;
for 24h;
Inert atmosphere;
|
|
|
With
thionyl chloride;
In
toluene;
at 20 - 80 ℃;
for 12h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
|
|
|
With
thionyl chloride;
for 2h;
Reflux;
|
|
|
With
thionyl chloride; N,N-dimethyl-formamide;
Inert atmosphere;
|
|
|
With
thionyl chloride;
In
toluene;
at 115 ℃;
for 16h;
|
|
|
With
thionyl chloride;
for 2h;
Heating / reflux;
|
|
|
With
thionyl chloride;
|
|
|
With
thionyl chloride;
at 25 - 70 ℃;
Inert atmosphere;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
for 2h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 2h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 - 25 ℃;
for 2h;
|
|
|
With
thionyl chloride;
In
dichloromethane;
at 60 ℃;
Inert atmosphere;
|
|
|
With
thionyl chloride;
at 80 ℃;
|
-
-
103-82-2
phenylacetic acid
-
-
36854-57-6
2-Phenylbutyryl chloride
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 20 - 25 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 - 25 °C
With
n-butyllithium; oxalyl dichloride; diisopropylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane; dichloromethane;
|
36854-57-6 Upstream products
-
90-27-7
2-Phenylbutyric acid
-
769-68-6
2-phenylbutanenitrile
-
103-82-2
phenylacetic acid
36854-57-6 Downstream products
-
101114-01-6
rac-2-phenyl-1-(pyrrolidin-1-yl)butan-1-one
-
108897-41-2
1-morpholino-2-phenylbutan-1-one
-
101866-38-0
2-phenyl-butyric acid-(2-piperidino-ethyl ester)
-
101739-47-3
2-phenyl-butyric acid-(2-piperidino-ethylamide)
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