hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one
- Name: hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one
- CAS: 71592-44-4
- Purity: 99%
Details
Manufacturer supply hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one 71592-44-4 with sufficient stock and high standard
- Molecular Formula: C13H17NO2
- Molecular Weight: 219.283
- Vapor Pressure: 0mmHg at 25°C
- Melting Point: 192-193℃
- Refractive Index: 1.555
- Boiling Point: 413.983 °C at 760 mmHg
- Flash Point: 204.17 °C
- PSA： 40.54000
- Density: 1.128 g/cm3
- LogP: 2.05600
hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one(Cas 71592-44-4) Usage
|
General Description |
Hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one, also known as trimebutine, is a chemical compound with pharmacological properties. It is used as a spasmolytic agent, mainly for the treatment of irritable bowel syndrome and other gastrointestinal disorders. Trimebutine works by reducing muscle spasms in the digestive tract, which helps to alleviate symptoms such as abdominal pain, bloating, and discomfort. It also has a mild analgesic effect, contributing to its efficacy in pain relief. Trimebutine is generally well-tolerated and has minimal adverse effects, making it a popular choice for the management of gastrointestinal conditions. |
InChI:InChI=1/C13H17NO2/c1-14-8-3-2-7-12(13(14)16)10-5-4-6-11(15)9-10/h4-6,9,12,15H,2-3,7-8H2,1H3
71592-44-4 Relevant articles
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents
DeSolms, S. Jane,Ciccarone, Terrence M.,MacTough, Suzanne C.,Shaw, Anthony W.,Buser, Carolyn A.,Ellis-Hutchings, Michelle,Fernandes, Christine,Hamilton, Kelly A.,Huber, Hans E.,Kohl, Nancy E.,Lobell, Robert B.,Robinson, Ronald G.,Tsou, Nancy N.,Walsh, Eileen S.,Graham, Samuel L.,Beese, Lorena S.,Taylor, Jeffrey S.
, p. 2973 - 2984 (2007/10/03)
A series of novel diaryl ether lactams h...
Inhibitors of prenyl-protein transferase
-
, (2008/06/13)
The present invention is directed to aze...
2-Bromo-3-methoxycyclohex-2-enone, a New Reagent for the α-Arylation of Lactams
Shepherd, Robin G.,White, Alan C.
, p. 2153 - 2156 (2007/10/02)
We report efficient syntheses of 2-bromo...
Process for making m-hydroxyphenyl substituted compounds
-
, (2008/06/13)
m-Hydroxyphenyl substituted compounds of...
71592-44-4 Process route
-
-
71556-70-2
hexahydro-1-methyl-3-(3-oxocyclohexen-1-yl) <2h> azepin-2-one
-
-
71592-44-4
hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one
| Conditions | Yield |
|---|---|
|
With
bromine;
In
dichloromethane;
at 30 ℃;
for 1h;
|
88%
|
|
Multi-step reaction
with
2
steps
1: 67 percent / 48percent HBr, KBrO3
/ H2
O / 1 h
2: 77 percent / 48percent HBr/acetic acid / CH2
Cl2
/ 3 h
With
potassium bromate; hydrogen bromide; acetic acid;
In
dichloromethane; water;
|
|
|
With
bromine;
In
dichloromethane; water; ethyl acetate;
|
-
-
87887-07-8
3-(2-chloro-3-oxocyclohex-1-enyl)hexahydro-1-methylazepin-2-one
-
-
71592-44-4
hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one
| Conditions | Yield |
|---|---|
|
With
hydrogen bromide; acetic acid;
In
dichloromethane;
for 3h;
|
|
|
With
hydrogen bromide;
In
water; acetic acid;
|
71592-44-4 Upstream products
-
71556-70-2
hexahydro-1-methyl-3-(3-oxocyclohexen-1-yl) <2h> azepin-2-one
-
87887-07-8
3-(2-chloro-3-oxocyclohex-1-enyl)hexahydro-1-methylazepin-2-one
-
87887-08-9
3-(2-bromo-3-oxocyclohex-1-enyl)hexahydro-1-methylazepin-2-one
-
71592-43-3
hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one
71592-44-4 Downstream products
-
27180-92-3
meptazinol hydrobromide
-
71556-72-4
3-Ethyl-hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one
-
59263-76-2
Meptazinol hydrochloride
-
71556-73-5
3-ethylhexahydro-3-(3-methoxyphenyl)-1-methyl <1h> azepine
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