Details
Quality products?make an important contribution to long-term revenue and profitability. Factory supply 1,4-Dichlorophthalazine 4752-10-7 with low price
1.What is the 1,4-Dichlorophthalazine ?
1,4-Dichlorophthalazine was used as starting reagent in the synthesis of series of 4-aryl-1-(4-methylpiperazin-1-yl)phthalazines. It was used as coupling reagent in the synthesis of novel soluble polymer-bound ligand. It was often used as building block in medicinal chemistry synthesis.
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-
253-52-1
PHTHALAZINE
-
-
5784-45-2
1-chlorophthalazine
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-
4752-10-7
1,4-dichlorophthalazine
| Conditions | Yield |
|---|---|
|
With
trichloroisocyanuric acid;
In
N,N-dimethyl-formamide;
at 40 - 50 ℃;
|
-
-
1445-69-8
2,3-dihydrophthalazine-1,4-dione
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-
4752-10-7
1,4-dichlorophthalazine
| Conditions | Yield |
|---|---|
|
With
chlorine; phosphorus trichloride;
In
chloroform;
at 105 ℃;
under 7500.75 Torr;
Reagent/catalyst;
Temperature;
|
97.9%
|
|
With
pyridine; trichlorophosphate;
for 1h;
Reflux;
|
93%
|
|
With
trichlorophosphate;
at 110 ℃;
for 1h;
|
90.1%
|
|
With
trichlorophosphate;
at 110 ℃;
for 1h;
|
90%
|
|
With
trichlorophosphate;
at 110 ℃;
|
90%
|
|
With
trichlorophosphate;
at 106 ℃;
|
90%
|
|
With
N,N-dimethyl-formamide; trichlorophosphate;
Heating;
|
90%
|
|
With
trichlorophosphate;
In
ethanol;
for 4h;
Reflux;
|
85%
|
|
With
trichlorophosphate;
Reflux;
|
84%
|
|
With
trichlorophosphate;
at 110 ℃;
for 1h;
|
83%
|
|
With
trichlorophosphate;
for 4h;
Reflux;
|
83.5%
|
|
With
phosphorus pentachloride; N,N-dimethyl-formamide;
for 7h;
Heating;
Inert atmosphere;
|
81%
|
|
With
trichlorophosphate;
for 4h;
Reflux;
|
81.2%
|
|
With
trichlorophosphate;
for 4h;
Reflux;
|
81.99%
|
|
With
phosphorus pentachloride; N,N-dimethyl-formamide;
at 145 ℃;
for 8h;
Inert atmosphere;
|
81%
|
|
With
trichlorophosphate;
Reflux;
|
81%
|
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene; phosphorus trichloride;
In
acetonitrile;
at 50 - 72 ℃;
for 10h;
Reagent/catalyst;
Temperature;
Autoclave;
Large scale;
|
80%
|
|
With
phosphorus pentachloride; N,N-dimethyl-formamide;
1.) r.t. -> 145 deg C, 60 min, 2.) 145 deg C, 4 h;
|
78%
|
|
With
trichlorophosphate;
In
N,N-dimethyl-formamide;
for 2h;
Heating / reflux;
|
39%
|
|
With
N,N-dimethyl-formamide; trichlorophosphate;
for 2h;
Inert atmosphere;
Reflux;
|
22.8%
|
|
With
trichlorophosphate;
In
N,N-dimethyl-formamide;
for 2h;
Reflux;
|
22.8%
|
|
With
phosphorus pentachloride;
|
|
|
With
trichlorophosphate;
|
|
|
With
trichlorophosphate;
Reflux;
|
|
|
With
trichlorophosphate;
at 110 ℃;
for 4h;
|
|
|
With
trichlorophosphate;
for 4h;
Reflux;
|
9 g
|
|
With
triethylamine; trichlorophosphate;
for 4h;
Reflux;
|
|
|
With
trichlorophosphate;
at 110 ℃;
for 3h;
|
|
|
With
trichlorophosphate;
at 80 - 110 ℃;
for 1h;
|
|
|
With
trichlorophosphate;
at 80 - 110 ℃;
for 1h;
|
|
|
With
trichlorophosphate;
|
|
|
With
trichlorophosphate;
at 110 ℃;
for 1h;
|
|
|
With
trichlorophosphate;
for 3h;
Inert atmosphere;
Reflux;
|
|
|
With
trichlorophosphate;
for 1h;
Heating;
|
2.What is the CAS number for 1,4-Dichlorophthalazine ?
The CAS number of 1,4-Dichlorophthalazine is 4752-10-7.
More information of 1,4-Dichlorophthalazine 4752-10-7 are:
|
CAS?Number |
4752-10-7 |
|
Density |
1.486 g/cm3 |
|
Melting Point |
160-162 °C(lit.) |
|
Boiling Point |
397.3 °C at 760 mmHg |
|
Flash Point |
226.4 °C |
|
Vapor Pressure |
3.67E-06mmHg at 25°C |
|
Refractive Index |
1.67 |
|
HS CODE |
29339900 |
|
PSA |
25.78000 |
|
LogP |
2.93660 |
|
Pka |
-0.44±0.30(Predicted) |
3.What are another words for 1,4-Dichlorophthalazine ?
Synonyms?for?1,4-Dichlorophthalazine 4752-10-7:Phthalazine,1,4-dichloro-;
4.What is the molecular formula of 1,4-Dichlorophthalazine?
The chemical formula of ?1,4-Dichlorophthalazine is?C8H4Cl2N2 which containing 8 Carbon atoms,4 Hydrogen atoms,2 Chlorine atoms and 2 Nitrogen atoms,and the molecular weight of??1,4-Dichlorophthalazine?is 199.039.
5.What is 1,4-Dichlorophthalazine (4752-10-7) used for?
1,4-Dichlorophthalazine is an organic compound that serves as a versatile building block in the field of medicinal chemistry. It is characterized by its chemical structure, which features a phthalazine ring with two chlorine atoms at the 1 and 4 positions. This unique structure allows it to be a valuable component in the synthesis of various pharmaceutical compounds.
InChI:InChI=1/C8H4Cl2N2/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H
Relevant articles related to 1,4-Dichlorophthalazine:
|
Article |
Source |
|
Structural identification between phthalazine-1,4-diones and n-aminophthalimides via vilsmeier reaction: Nitrogen cyclization and tautomerization study |
Chung, Cheng-Yen,Li, Sin-Min,Lin, Hui-Yi,Tsai, Shuo-En,Tseng, Ching-Chun,Wong, Fung Fuh , (2021/05/31) |
|
Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors |
Frett, Brendan,Kharbanda, Anupreet,Leung, Yuet-Kin,Li, Hong-yu,Li, Ming O.,Saha, Debasmita,Tran, Phuc,Xu, Ke,Zhang, Lingtian supporting information, (2021/07/13) |
6.Buy 1,4-Dichlorophthalazine with the best price .
Changzhou Longterm Biotechnology Co., Ltd. is a quality supplier of 1,4-Dichlorophthalazine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 1,4-Dichlorophthalazine 4752-10-7.
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